Teratology testing in nonventilated pregnant rats treated subcutaneously with maximum subparalyzing doses (4 mg/kg daily; equivalent to 8 Г— the human ED95 following a bolus dose of 0.2 mg/kg IV) and in ventilated rats treated intravenously with paralyzing doses of NIMBEX at 0.5 and 1.0 mg/kg; equivalent to 10В Г—В and 20 Г— the human ED95 dose, respectively, revealed no maternal or fetal toxicity or teratogenic effects.
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Medications are most effective when taken in anticipation of the involuntary motion; they are less effective for symptom relief after the motion has begun.
In patients at high immunologic risk (defined as Black transplant recipients and/or repeat renal transplant recipients who lost a previous allograft for immunologic reason and/or patients with high-panel reactive antibodies [PRA; peak PRA level > 80%]), it is recommended that Rapamune be used in combination with cyclosporine and corticosteroids for the first year following transplantation (see [#section-6 CLINICAL STUDIES, ][#section-13 DOSAGE AND ADMINISTRATION]). The safety and efficacy of this combination in high-risk patients have not been studied beyond one year; therefore, after the first year following transplantation, any adjustments to the immunosuppressive regimen should be considered on the basis of the clinical status of the patient.
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This new knowledge mainly emanates from civilian research into, e.g., the treatment of cancer patients.
Cheyne-Stokes respiration and apnea may occur.