The more common adverse reactions in Prograf-treated heart transplant recipients were abnormal renal function , hypertension, diabetes mellitus, CMV infection, tremor, hyperglycemia, leukopenia, infection, and hyperlipemia.
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Probenecid slows tubular secretion and produces even higher serum levels, increasing the duration of measurable serum concentrations.
In 1876, Robert Koch, a Prussian physician, isolated the anthrax bacillus and pointed out that the bacillus could form spores which remained viable, even in hostile environments.