The Berlin Aging Study, a population-based study of functionally healthy volunteers 70 to 100 years of age, found a 4% prevalence of 75% carotid stenoses among both men and women.
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With the use of real-time quantitative polymerase chain reaction, significant expression of IL-18 messenger RNA was found in human carotid atherosclerotic plaque as compared with little or no expression in normal arteries.
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