The potassium-sparing action of spironolactone may predominate and hyperkalemia may occur, especially in patients with impaired renal function.
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The intensity of this odor may vary over time.
In elderly and debilitated patients, it is recommended that the dosage be limited to the smallest effective amount to preclude the development of ataxia or oversedation (2 mg to 2ВЅ mg once or twice daily, initially, to be increased gradually as needed and tolerated).
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Calcium excretion is decreased by thiazides.
In one patient, perforation also occurred.